The Paredes Lab

neurodevelopment and disease

The Paredes Lab studies cortical development to understand the molecular and cellular basis of neuropsychiatric conditions, such as epilepsy and brain malformations. Our hypothesis is that the gyrencephalic brain has evolved developmental processes and a prolonged timeline that, when disrupted, will lead to cortical disorganization and aberrant connectivity. We are currently focused on identifying features of neuronal progenitor proliferation and migration, with an emphasis on the perinatal period, that are unique to the gyrated brain. Our approach is to advance ways to directly investigate the human brain and to better model its development using gyrencephalic systems like the piglet cortex.

Implications of Extended Inhibitory Neuron Development.

International journal of molecular sciences

Kim JY, Paredes MF

Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sorrells SF, Paredes MF, Zhang Z, Kang G, Pastor-Alonso O, Biagiotti S, Page CE, Sandoval K, Knox A, Connolly A, Huang EJ, Garcia-Verdugo JM, Oldham MC, Yang Z, Alvarez-Buylla A

Interneuron Origins in the Embryonic Porcine Medial Ganglionic Eminence.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Casalia ML, Li T, Ramsay H, Ross PJ, Paredes MF, Baraban SC