The Neonatal Gyrencephalic Cortex Maintains Regionally Distinct Streams of Neuroblasts.

MS ID#: BIORXIV/2023/543768

JaeYeon Kim, Kadellyn Sandoval, Aunoy Poddar, Julia Chu, Emma Horton, Di Cui, Keira Nakamura, Theresa Bartels, Christian Wood, David H. Rowitch, Hosung Kim, Chet C. Sherwood, Boris W Kramer, Angela C. Roberts, Pablo J. Ross, Duan Xu, Nicola J. Robertson, Peng Ji, Elizabeth A. Maga, Mercedes F. Paredes

A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion.

Scientific Reports 13:7689 (2023)

Neha Paranjape, Yu‑Hsiu T. Lin, Quetzal Flores‑Ramirez, Vishesh Sarin, Amanda Brooke Johnson, Julia Chu, Mercedes Paredes & Arun P. Wiita

Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain.

Cell. 2022 09 29; 185(20):3753-3769.e18. 

Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-Granero S, Lozano JF, Vento M, Haeussler M, Paredes MF, Nakamura K, Garcia-Verdugo JM, Alvarez-Buylla A, Kriegstein AR, Huang EJ

Cell Migration in the Mammalian Cortex.

Neuroscience in the 21st Century. Springer, New York, NY. 2022 Jun 29; 1-18.

Kim KJ, Pleasure PS, Paredes PM

Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".

Science. 2022 04 15; 376(6590):eabn8861.

Alvarez-Buylla A, Cebrian-Silla A, Sorrells SF, Nascimento MA, Paredes MF, Garcia-Verdugo JM, Yang Z,Huang EJ

The development and evolution of inhibitory neurons in primate cerebrum.

Nature. 2022 03; 603(7903):871-877.

Schmitz MT, Sandoval K, Chen CP, Mostajo-Radji MA, Seeley WW, Nowakowski TJ, Ye CJ, Paredes MF, Pollen AA

Nests of dividing neuroblasts sustain interneuron production for the developing human brain.

Science. 2022 01 28; 375(6579):eabk2346.

Paredes MF, Mora C, Flores-Ramirez Q, Cebrian-Silla A, Del Dosso A, Larimer P, Chen J, Kang G, Gonzalez Granero S, Garcia E, Chu J, Delgado R, Cotter JA, Tang V, Spatazza J, Obernier K, Ferrer Lozano J, Vento M, Scott J, Studholme C, Nowakowski TJ, Kriegstein AR, Oldham MC, Hasenstaub A, Garcia-Verdugo JM, Alvarez-Buylla A, Huang EJ

Amplification of human interneuron progenitors promotes brain tumors and neurological defects.

Science. 2022 01 28; 375(6579):eabf5546. 

Eichmüller OL, Corsini NS, Vértesy Á, Morassut I, Scholl T, Gruber VE, Peer AM, Chu J, Novatchkova M, Hainfellner JA, Paredes MF, Feucht M, Knoblich JA

Implications of Extended Inhibitory Neuron Development.

International journal of molecular sciences. 2021 May 12; 22(10)

Kim JY, Paredes MF

Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021 03 24; 41(12):2554-2565.

Sorrells SF, Paredes MF, Zhang Z, Kang G, Pastor-Alonso O, Biagiotti S, Page CE, Sandoval K, Knox A, Connolly A, Huang EJ, Garcia-Verdugo JM, Oldham MC, Yang Z, Alvarez-Buylla A

Interneuron Origins in the Embryonic Porcine Medial Ganglionic Eminence.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021 04 07; 41(14):3105-3119. 

Casalia ML, Li T, Ramsay H, Ross PJ, Paredes MF, Baraban SC

Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon.

Cell reports. 2020 10 13; 33(2):108256.

Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J

Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation.

ELife. 2020 05 26; 9.

Pai EL, Chen J, Fazel Darbandi S, Cho FS, Chen J, Lindtner S, Chu JS, Paz JT, Vogt D, Paredes MF, Rubenstein JL

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map.

Nature neuroscience. 2020 04; 23(4):500-509.

Bayraktar OA, Bartels T, Holmqvist S, Kleshchevnikov V, Martirosyan A, Polioudakis D, Ben Haim L, Young AMH, Batiuk MY, Prakash K, Brown A, Roberts K, Paredes MF, Kawaguchi R, Stockley JH, Sabeur K, Chang SM, Huang E, Hutchinson P, Ullian EM, Hemberg M, Coppola G, Holt MG, Geschwind DH, Rowitch DH

Cortical Malformations: Lessons in Human Brain Development.

Frontiers in cellular neuroscience. 2019; 13:576.

Subramanian L, Calcagnotto ME, Paredes MF

Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.

Brain communications. 2019; 1(1):fcz027.

Miller ZA, Spina S, Pakvasa M, Rosenberg L, Watson C, Mandelli ML, Paredes MF, Joie R, Rabinovici GD, Rosen HJ, Grinberg LT, Huang EJ, Miller BL, Seeley WW, Gorno-Tempini ML

Building Bridges Between the Clinic and the Laboratory: A Meeting Review - Brain Malformations: A Roadmap for Future Research.

Frontiers in cellular neuroscience. 2019; 13:434.

Sapir T, Barakat TS, Paredes MF, Lerman-Sagie T, Aronica E, Klonowski W, Nguyen L, Ben Zeev B, Bahi-Buisson N, Leventer R, Rachmian N, Reiner O

Immature excitatory neurons develop during adolescence in the human amygdala.

Nature communications. 2019 06 21; 10(1):2748. 

Sorrells SF, Paredes MF, Velmeshev D, Herranz-Pérez V, Sandoval K, Mayer S, Chang EF, Insausti R, Kriegstein AR, Rubenstein JL, Manuel Garcia-Verdugo J, Huang EJ, Alvarez-Buylla A

Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex.

Neuron. 2019 04 03; 102(1):143-158.e7.

Mayer S, Chen J, Velmeshev D, Mayer A, Eze UC, Bhaduri A, Cunha CE, Jung D, Arjun A, Li E, Alvarado B, Wang S, Lovegren N, Gonzales ML, Szpankowski L, Leyrat A, West JAA, Panagiotakos G, Alvarez-Buylla A, Paredes MF, Nowakowski TJ, Pollen AA, Kriegstein AR

Does Adult Neurogenesis Persist in the Human Hippocampus?

Cell Stem Cell. 2018 12 06; 23(6):780-781.

Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A

Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.

Cerebral Cortex. 2018 06 01; 28(6):1946-1958.

Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells SF, Kelley KW, Nicholas CR, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL, Oldham MC

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.

Nature. 2018 03 15; 555(7696):377-381. 

Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A

Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism.

Cell Reports. 2018 02 13; 22(7):1695-1709. 

Priya R, Paredes MF, Karayannis T, Yusuf N, Liu X, Jaglin X, Graef I, Alvarez-Buylla A, Fishell G

No Evidence For New Adult Neurons.

American Scientist. 2018 Jan 1; 106(3):152. 

Sorrells SS, Alvarez-Buylla AA, Paredes PM. 

Dynamic behaviour of human neuroepithelial cells in the developing forebrain.

Nature communications. 2017 01 31; 8:14167. 

Subramanian L, Bershteyn M, Paredes MF, Kriegstein AR

Extensive migration of young neurons into the infant human frontal lobe.

Science. 2016 Oct 07; 354(6308). 

Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen PS, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A

Brain size and limits to adult neurogenesis.

The Journal of comparative neurology. 2016 Feb 15; 524(3):646-64.

Paredes MF, Sorrells SF, Garcia-Verdugo JM, Alvarez-Buylla A

Encephalitis and AMPA receptor antibodies: Novel findings in a case series of 22 patients.

Neurology.  2015 Jun 16; 84(24):2403-12. 

Höftberger R, van Sonderen A, Leypoldt F, Houghton D, Geschwind M, Gelfand J, Paredes M, Sabater L, Saiz A, Titulaer MJ, Graus F, Dalmau J

Distinct and separable roles for EZH2 in neurogenic astroglia.

Neuro-Oncology. 2014 Jul 1; 16(suppl_3):iii17-iii17.

Hwang HW, Salinas SR, Siu SJ, Kelley KK, Delgado DR, Paredes PM, Alvarez-Buylla AA, Oldham OM, Lim LD. 

Axons take a dive: Specialized contacts of serotonergic axons with cells in the walls of the lateral ventricles in mice and humans.

Neurogenesis (Austin, Tex.) 2014 Jan 01; 1(1).

Tong CK, Cebrián-Silla A, Paredes MF, Huang EJ, García-Verdugo JM, Alvarez-Buylla A

Intrinsically determined cell death of developing cortical interneurons.

Nature. 2012 Nov 01; 491(7422):109-13. 

Southwell DG, Paredes MF, Galvao RP, Jones DL, Froemke RC, Sebe JY, Alfaro-Cervello C, Tang Y, Garcia-Verdugo JM, Rubenstein JL, Baraban SC, Alvarez-Buylla A

Hilar mossy cells share developmental influences with dentate granule neurons.

Developmental neuroscience.  2008; 30(4):255-61.

Li G, Berger O, Han SM, Paredes M, Wu NC, Pleasure SJ

Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus.

Developmental neuroscience. 2007; 29(1-2):48-58. 

Berger O, Li G, Han SM, Paredes M, Pleasure SJ

Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Sep 13; 26(37):9404-12.

Paredes MF, Li G, Berger O, Baraban SC, Pleasure S

Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia.

The Journal of comparative neurology. 2006 Mar 01; 495(1):133-48.

Paredes M, Pleasure SJ, Baraban SC

Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Oct 19; 25(42):9649-57. 

Calcagnotto ME, Paredes MF, Tihan T, Barbaro NM, Baraban SC

Neuropeptide Y modulates a G protein-coupled inwardly rectifying potassium current in the mouse hippocampus.

Neuroscience letters. 2003 Apr 03; 340(1):9-12.

Paredes MF, Greenwood J, Baraban SC

Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Sep 01; 22(17):7596-605.

Calcagnotto ME, Paredes MF, Baraban SC

A review of gene expression patterns in the malformed brain.

Molecular neurobiology. 2002 Aug; 26(1):109-16.

Paredes MF, Baraban SC